OYAH INGREDIENT LIBRARY

Melatonin

Melatonin is a hormone involved in circadian timing. Study results depend heavily on when it is taken, the amount, formulation and the reason for sleep disruption.

Evidence reviewUpdated 11 October 2026
MSleep timing / hormone
Evidence signalSmall average sleep effects; timing is central
Research focusSleep onset, total sleep time and circadian timing
Key qualifierTiming, formulation, population and sleep condition

What it is

The brain releases melatonin in response to darkness as part of the sleep-wake timing system. Supplemental melatonin changes the signal presented to that system. Immediate-release and prolonged-release formulations can behave differently.

What human research suggests

Meta-analyses report small average improvements in sleep onset, total sleep time or sleep quality in selected populations. Effects vary across primary insomnia, circadian disorders, jet lag and secondary sleep problems. A result in one condition does not establish the same benefit for every sleep complaint or for a multi-ingredient formula.

HOW THIS RELATES TO OYAH

Melatonin in an OYAH formula.

The related product page shows the current ingredient list and directions. Compare those details with each paper before deciding how closely the evidence applies. OYAH does not claim that the finished formula was tested in the linked studies.

Sleep & RestoreView Sleep & Restore
Ingredient studyTests a defined ingredient, preparation and protocol.Finished-product evidenceWould require a clinical trial of the complete formula.Certificate of AnalysisReports the tests shown for a sample or lot; it does not establish benefit.
SAFETY & CONTEXT

What to consider before use.

Possible effects include daytime drowsiness, headache, dizziness and vivid dreams. Melatonin may interact with anticoagulants, sedatives, anticonvulsants, diabetes medicines and immunosuppressants. Avoid driving after taking it. Children, pregnant or breastfeeding people, and anyone with a seizure, autoimmune or significant medical condition should seek clinical guidance first.

This guide is educational and is not medical advice. Speak with a qualified healthcare professional about pregnancy, breastfeeding, medical conditions, medicines, surgery or persistent symptoms.

READ THE SOURCES

Follow the evidence.

Each link opens the publication, indexed record or government guidance. Study findings remain limited to the preparation and protocol researchers examined.

  1. Melatonin and primary sleep disorders2013 meta-analysis · PMID 23691095 ↗
  2. Melatonin supplementation and sleep quality2021 systematic review and meta-analysis · PMID 33417003 ↗
  3. Timing and amount of melatonin2024 systematic review and dose-response meta-analysis · PMID 38888087 ↗
  4. NCCIH: Melatonin—what you need to knowGovernment safety and interaction guidance ↗
Current product directory

Know the product. Read the evidence.

Compare the current OYAH range, then open the product-specific evidence and ingredient guides. Ingredient studies do not establish the benefits of a finished OYAH formula.