OYAH INGREDIENT LIBRARY

NAD+

NAD+ is essential to cellular metabolism, but direct oral NAD+, NADH, nicotinamide riboside and nicotinamide mononucleotide are different interventions. Evidence cannot move freely between them.

Evidence reviewUpdated 11 October 2026
NCellular metabolism / coenzyme
Evidence signalBiomarker research is active; clinical benefit remains unproven
Research focusNAD-related metabolites, ageing and metabolic outcomes
Key qualifierDirect NAD+ versus NADH, NR or NMN

What it is

Nicotinamide adenine dinucleotide is a coenzyme used in energy metabolism and cellular reactions. NAD+ levels and metabolism change with age and health, but that biological importance does not show that swallowing NAD+ produces a clinical outcome.

What human research suggests

Human trials more commonly study precursors such as nicotinamide riboside or nicotinamide mononucleotide. Some raise NAD-related blood metabolites, but biomarker movement is not the same as improved energy, cognition or longevity. Direct oral NAD+ has a smaller human evidence base, and there is no basis for a lifespan claim.

HOW THIS RELATES TO OYAH

NAD+ in an OYAH formula.

The related product page shows the current ingredient list and directions. Compare those details with each paper before deciding how closely the evidence applies. OYAH does not claim that the finished formula was tested in the linked studies.

NAD+View NAD+
Ingredient studyTests a defined ingredient, preparation and protocol.Finished-product evidenceWould require a clinical trial of the complete formula.Certificate of AnalysisReports the tests shown for a sample or lot; it does not establish benefit.
SAFETY & CONTEXT

What to consider before use.

Safety data depend on the exact NAD-related compound, amount and duration. Findings from NR or NMN cannot define the safety of direct oral NAD+. People who are pregnant or breastfeeding, have cancer, liver or kidney disease, or use regular medicines should ask a healthcare professional before using NAD-related supplements.

This guide is educational and is not medical advice. Speak with a qualified healthcare professional about pregnancy, breastfeeding, medical conditions, medicines, surgery or persistent symptoms.

READ THE SOURCES

Follow the evidence.

Each link opens the publication, indexed record or government guidance. Study findings remain limited to the preparation and protocol researchers examined.

  1. NAD+ and NADH supplementation in humans2024 systematic review · PMID 37971292 ↗
  2. Nicotinamide riboside and NAD+ metabolism2018 randomized crossover trial · PMID 29599478 ↗
  3. NMN efficacy and safety2023 systematic review and meta-analysis · PMID 36482258 ↗
  4. NMN amount and blood NAD concentration2024 post-hoc analysis of a clinical trial · PMID 38430946 ↗
Current product directory

Know the product. Read the evidence.

Compare the current OYAH range, then open the product-specific evidence and ingredient guides. Ingredient studies do not establish the benefits of a finished OYAH formula.